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Familial Shar Pei Fever and Amyloidosis

  


Written by: Jeff Vidt, DVM 

Familial Shar-Pei Fever (FSF) is a hereditary inflammatory disorder
seen in Shar-Pei. It is inherited as an autosomal recessive condition. 

Clinical signs:
Episodic fever is the most important and consistent clinical sign of 
this disorder. The temperature commonly is in the 105-107°F range. The 
fever is generally self-limiting lasting 12-36 hours. Another common 
clinical sign often accompanying the fever is swelling of a joint,
usually the hock (tibiotarsal) joint and is known as Swollen Hock 
Syndrome (SHS). This painful, hot swelling can also involve the carpus 
(wrist) and the lips. Dogs with FSF are sick -- they are reluctant to 
move and when they do walk they have a characteristic "walking on 
eggs" gait. They often are painful in the abdomen and have 
a characteristic "roached" back.

Pathogenesis:

What we do know about this disease is as follows: 
Shar-Pei with FSF have increased levels of the cytokine Interleukin-6 
(IL-6). IL-6 is involved with the fever response and and is an integral 
part of triggering the production of Acute Phase Reactant Proteins by 
the liver. IL-6 is also involved in the Systemic Inflammatory Response 
Syndrome(SIRS). 
Dysregulation of IL-6 is the cause of much of the disease in Shar-Pei 
with FSF. IL-6 also plays a major role in the body's stress response 
and serves to "prime" the immune system. Shar-Pei with FSF are at risk 
from early death from systemic amyloidosis. About 25% of the FSF dogs 
will develop renal failure including renal amyloidosis -- a smaller 
percentage will develop hepatic amyloidosis. This is usually seen in 
Shar-Pei between the ages of 2-5 years of age. 
They also seem more susceptible to immune-mediated kidney disease, 
such as membranous glomerulonephritis, protein-losing glomerulopathies, 
DIC, thromboembolic phenomena such as mesenteric, splenic and pulmonary 
embolism and Streptococcal Toxic Shock Syndrome (STSS). FSF in Shar-Pei 
was hypothesized to be an animal model of Familial Mediterranean Fever 
(FMF) in humans. Recent work indicates this is not true, although FSF is 
very similar to FMF in man. FSF is a heredofamilial disease with a 
genetic basis. It appears to be inherited as an autosomal recessive 
condition. 

Laboratory Findings:
Unfortunately there are no blood test, etc. which are specific for FSF.
During a fever episode there will often be an increased white blood cell
count, an increase in liver enzyme levels and other non-specific findings. 
Work done by Dr. Gary Johnson at the University of Missouri College 
of Veterinary Medicine to develop a DNA blood test to screen for the 
disease was unsuccessful and the research effort will still continue.

Treatment:
It is very important to monitor the temperature in this condition. 
Initially, fever can be treated using aspirin. Usually a regular 
strength adult aspirin is given every 6 hours for the first 24 hours 
and then twice a day for 3-5 day thereafter. In rare cases where 
aspirin doesn't work of for extremely high fevers, dipyrone is given. 
Some patients will require supportive care with intravenous fluid 
therapy and in extreme cases emergency treatment similar to heat stroke 
treatment. Antibiotics are not normally indicated in this condition. 

Colchicine:
Colchicine is a drug that has been in use in people with FMF to 
prevent amyloidosis. It is currently being recommended in Shar-Pei 
with FSF for the same purpose. No studies have been completed to 
determine if it is useful for this purpose in the Shar-Pei or not. 
The clinical impression is that it does help. Those dogs on colchicine 
seem to have fewer FSF episodes and less severe signs while on the drug.
Side-effects appear to be minimal at this time and are primarily
gastrointestinal, such as vomiting, diarrhea, anorexia 
(decreased appetite), etc.

Prevention:
Shar-Pei with FSF only show symptoms sporadically. It would appear that 
there are "triggers" involved in initiation of the FSF episodes. One of 
the major triggers appears to be stress. This may be a dog training class, 
a dog show, another illness, a dog in heat, excessive exercise, etc. If 
the owner can recognize these triggers and take steps to avoid them the 
number of FSF episodes can often be reduced. Diet does not appear to be 
helpful in prevention of FSF or kidney disease. Surely diet has a role in 
the management of the kidney disease once clinical signs are apparent. 
Low dose aspirin therapy may be useful in decreasing the incidence of FSF 
and its severity as well. Aspirin may also be useful as an adjunct therapy 
in the prevention of thromboembolism. 


Monitoring:
Monitoring for the complications which often accompany FSF is one of the 
major goals of the owner of an FSF dog. The primary and most consistent 
sequela to FSF is kidney failure either due to immune-mediated kidney 
disease or renal amyloidosis. I currently recommend monitoring a 
urinalysis every 3 months. The sample should be collected first thing 
in the morning after the water has been taken up overnight. I primarily 
look at the urine specific gravity which is a measure of the concentration 
of the urine and the protein levers in the urine. When the kidneys begin 
to fail the initial indication is a loss in the ability to produce a 
concentrated urine. This occurs before there are blood changed related 
to  kidney failure. Increased water consumption, increased urination are 
the clinical signs associated with the loss of concentrating ability, but 
these signs are often not recognized. I also think it is wise to do a 
blood panel every 6-12 months and certainly do one in the urinalysis 
is abnormal. Weighing your dog periodically is very important. We often 
don't recognize a significant weight loss because it is very subtle over 
a longer period of time. Water consumption and appetite are other 
important indicators to watch. 

Complications of FSF:
We have already discussed the kidney complications in this condition. 
Other Complications which have been documented include thromboembolism
(mesenteric, splenic, pulmonary), DIC (disseminated intravascular 
coagulation), SIRS (systemic inflammatory response syndrome), MODS 
(multiple organ dysfunction syndrome), STSS (streptococcal toxic shock
syndrome), hypertension associated with renal failure. Many of the deaths
following an acute FSF episode are due to these complications. No FSF 
episode should be treated lightly! 


Diagnosis:
There is no specific diagnostic test for FSF at this time. Diagnosis is 
based on the clinical sign of episodic fever in a Shar-Pei. I think every 
Shar-Pei that dies should be autopsied to determine the cause of death, 
but this is even more critical in cases involving FSF. Renal amyloidosis 
can only be diagnosed based on kidney biopsy and staining with Congo Red
stain. This stain is specific for the presence of amyloid. Amyloid has 
been found in other tissues in Shar-Pei as well so special staining should 
be requested on all tissues submitted for histopathology. Many dogs with 
FSF will not have amyloid in the tissues at the time the tissues were
harvested...this means the absence of amyloid in a biopsy specimen does 
not mean that dog will not or would not have gone on to develop amyloidosis 
at a later time. To further confuse the issue, not all Shar-Pei
with amyloidosis have shown signs of FSF. 

Future:
Research is currently underway at the University of Missouri College of
Veterinary Medicine by Dr. Gary Johnson to develop a DNA blood test. The 
gene for human FMF was sequenced in the Fall of 1997 and with that 
information Dr. Johnson had hoped to sequence the FSF gene. That information
was applied by Dr. Gary Johnson to FSF in a research project founded by the
CSPCA Charitable Trust. That project did determine that the mutations causing
FMF in man do not exist in FSF in the Shar-Pei, hence they are two distinct,
although similar diseases. There are other hereditary inflammatory fever
disorders in man and Dr. Kastner ant the National Institutes of Health are
looking at the disorder with information supplied by Dr. Tintle. Familial
Hibernian Fever in man has also been ruled out as the cause of FSF by Dr.
Johnson with information supplied by NIH. Work will continue to find the
genetic mutation(s) responsible for FSF in Shar-Pei.

As of this writing the mutation responsible for FSF has not been found.
If a test can be developed, a screening program can be established to screen
breeding stock and determine normal individuals, carriers and affected dogs.
With this information Shar-Pei breeders can gradually eliminate this genetic
disease from the breed. One of the major obstacles to research revolves around
the unpredictable phenotype of FSF. There is no consistent age range when
clinical signs develop, the clinical signs can be variable, some dogs develop
amyloidosis, some don't, etc. This makes it very difficult to use genetic
selection methods which are based on phenotype. 

Recommendations:
All Shar-Pei with FSF should be on colchicine and be regularly monitored via
urine samples and blood work for development of complications. Dogs with FSF
should not be used in breeding programs and should be neutered. Dogs with a
family history of FSF should be on colchicine and monitored. Dogs with FSF
should be maintained as stress-free as possible.


Dr. Linda Tintle
UPDATE ON RESEARCH AND REQUEST FOR SAMPLES FROM DOGS WITH FSF
DURING A FEVER EVENT AS WELL AS IN BETWEEN FSF EPISODES
As part of our CSP Charitable Trust-AKC/CHF funded study, Dr. Anne Avery is
looking for blood samples from dogs with FSF (Familial Shar-Pei Fever) at the
time they are spiking a fever. Please have your veterinarian obtain 6-10 ml 
of EDTA whole blood (lavender top tube) and the serum from 3-5 ml blood (red
top or serum separator tube) and contact Dr. Avery at (970) 491-1170 to
arrange overnight shipment of the samples to: Dr. Anne Avery, Dept. of MIP,
1619 Campus Delivery, Fort Collins, CO 80523-1619 by overnight express. You
will need to provide a signed consent form, the dogs AKC number and complete
a questionnaire which can be faxed or e-mailed to you. Shipping costs via UPS
will be covered by the research grant an (account number will be provided for
billing) but there is no funding available to reimburse you for veterinary
expenses. Please help. She also still needs samples from ANY dog with a
history of FSF episodes. Your cooperation will benefit your dog and the entire
breed. 
Preliminary results have shown that a statistically significant greater number
of Shar-Pei with FSF or Shar-Pei with close relatives with FSF/A have elevated
background levels of IL-6. Shar-Pei without evidence of FSF and no close
relatives with FSF/A did not have statistically significantly elevated
background levels of IL-6. This was shown in my study with Cornell and
confirmed by Dr. Avery's recent testing. So far, it looks like SAA and CRP
levels are all over the place and do not correlate with health or disease but
analysis is on-going. Also, no Shar-Pei (with or without FSF) that Dr. Avery
examined had elevated levels of TNF-á. Serum IL-10 and HA (hyaluronan or
mucin) levels are next. We do not know yet if serum HA levels correlate with
their auto-inflammatory disease. All we can do at this time is speculate which
is why that research is a priority. I am also working to get Dr. Avery's study
to include checking levels of IL-1â as soon as possible because this has been
implicated in some of the human periodic fever disorders. Since IL-6 is one of
the main chemical signals to turn on the acute phase reactant proteins (the
precursors of amyloid A), chronic elevation of IL-6 in FSF patients is not a
surprising finding. My study with immunologists Ariel Rivas and Fred Quimby at
Cornell in the early '90s suggested that there may be problem with 
down-regulation of IL-6 so we are going to take another look at that
(a blocked receptor for an IL-6 inhibitor?)

The studies are as yet incomplete. S-P had dramatically elevated levels of IL-
and SAA during fever events. We are looking for samples from more dogs during
events (see above). These elevations are not unexpected because these are the
messengers of inflammation but we want to compare their response to normal
controls to see if they are exaggerated.
The problem with IL-6 as a test is that not every dog with FSF had elevated
background levels - there may be a lot of false negatives so I don't know how
useful it might prove as a diagnostic test. One of the other cytokines yet to
be examined may prove to be more predictive. A specific genetic mutation that
is shared by all Shar-Pei with FSF would be ideal the elusive holy grail of
tests. Linkage studies for this will be starting as soon as we can get all the
information possible on the dogs in the pedigrees being examined by Dr. Puppo
at the NIH. (Very soon).
My heartfelt thanks to Barbara LaVere, Pat Zimmel-Roach, Alice Fix, Dr. Jeff
Vidt and all the members of the Centennial Club in the Colorado area (too
numerous to list but without which Dr. Avery's project would not be moving
forward!) and the many CSPCA members who have so kindly taken the time to
provide information for the pedigree analysis component of the DNA study at
the NIH. Dr. Avery told me today how enormously impressed she is by the
lengths to which Shar-Pei breeders have been willing to go to help with this
project. Shar-Pei people are as special as their dogs!
Dr. Linda Tintle
Wurtsboro Veterinary Clinic
163 Sullivan Street, PO Box 910
Wurtsboro, New York 12790
wvc@warwick.net
www.wvc.vetsuite.com
April 14, 2006




Other Breed Health Issues

  

Health Issues that may effect the Shar-Pei
In general, dogs with any of the following conditions should not be bred. 
You want to make sure that the parents of the puppy you may be considering
have been cleared or checked for any of these conditions.
If your veterinarian requires more information about the Chinese Shar-Pei,
send the name and address of your veterinarian (for overseas orders, send
$2.00 in U.S. funds for postage) to:
Jeff Vidt, DVM
210 S. Park Street
Westmont, IL 60559-1940

ENTROPION

The Shar-Pei are 1 of 14 breeds that can have this condition. This is where the eyelid rolls in towards the eye, rubbing against the cornea and irritating this sensitive structure. Watery eyes, infection, even a corneal ulcer, can occur. Surgical correction may be required. Dogs with this Primary Entropion should not be bred, as a genetic component is suspected.

EYE TACKING

Puppies open their eyes at about 10-14 days of age. In Shar-Pei, this is often when the first symptoms of entropion appear. Typically the puppies open their eyes, but quickly they begin squinting and closing them. Often there is a mucous eye discharge and these puppies usually don't eat well or gain weight like their littermates. EYE TACKING is a temporary measure in which sutures (stitches) are placed in the eye lids to roll the lids "out" of the eyeball. Often this can be done without anesthesia in very young puppies (2-4 weeks of age). Sometimes gas anesthesia is used. Nylon sutures or surgical staples are placed in or near the eyelids which opens the eyes. Often an antibiotic eye ointment is dispensed to help heal any corneal ulcers and prevent secondary bacterial infections. These sutures are left in place for as long as possible, up to 4 weeks in some cases. The tacks can be replaced as needed until a permanent repair procedure can be done. If the sutures loosen up or are causing problems, they can be removed. Eye tacking can result in permanent repair of entropian, but its primary goal is to prevent serious eye damage until the pup is old enough to undergo permanent entropion repair - around 12 months of age or the puppy grows into the excess skin resolving the entropian issue. Puppies who have their eyes tacked may or may not need permanent entropion repair later on - there is not much correlation between the two. ENTROPION IN YOUNG PUPPIES CAN RESULT IN CORNEAL ULCERATION AND IS A MEDICAL EMERGENCY - SEE YOUR VET IMMEDIATELY!

ENTROPION REPAIR

Permanent ENTROPION SURGERY is often done in Shar-Pei after they reach the age of 12 months old. This is the age at which most pups are full grown and have "grown into" their heads. Permanent repair is a surgical procedure that will result in correction of any structural problem with the eyelids. Its success depends on the experience and artistry of the surgeon and often times referral to a veterinary ophthalmologist is recommended. Generally a regular Vet who is experienced with the breed will serve best. The procedure involves various techniques to remove excessive eyelid tissue from the lids, tighten up the eye opening and sometimes remove extra folds of skin around the eyes. Typically the dogs look worse for a few days after the surgery due to the swelling that occurs and they often sport an Elizabethan or "lampshade" collar to protect the sutures. Stitches are usually removed in 7-14 days unless dissolvable stitches are used. It should be noted that CSP’s eyes can be very sensitive or allergic to irritants and their eyes can swell shut due to environmental allergens (dust, cigarette smoke), this can cause the appearance of entropion but doing the surgery will not solve the problem. Tracking down the offending allergen and removing it from the environment will correct the problem. Entropion can also be cause by stress – commonly referred to as "stress entropion" – this is again a temporary situation and once the dog is removed from the stressful situation, the eyes will recover. If their cornea gets a scratch, or if they bump their eye again the tissue surrounding the eye can swell, causing the eye to shut, tacking is advised for these situations, as it is a temporary problem. There are rare incidents where an injury or allergic reaction with prolonged, sustained swelling can damage the structure of the lid causing Secondary Entropion. This is not a genetic issue unless there was a pre-existing Primary Entropion issue. We had one who sustained this after sustained severe swelling of the face and lids following a severe reaction to spider toxins.

CHERRY EYE

Cherry eye – protrusion of the third eyelid - is another fairly common problem in the breed. The gland for the third eyelid becomes unattached and can be seen a round red blob in the inner corner of the eye. When particularly large it can in fact obscure the entire eye. Whilst it doesn’t hurt the dog or affect it in any way it is unsightly and if left untreated can cause problems. Treatment consists of surgery to place the gland back into place and tie it down with sutures. This type of surgery is generally very successful though there are rare occurrences when the gland pops back out. If this should happen then it is generally recommended that the entire gland be removed. Should the gland itself be removed then drops have to be put in the dog’s eye for the rest of its life to prevent what is commonly referred to as "dry" eye. It should be noted that if one of the glands comes lose, the other eye will also be affected. Should this happen to your dog it is worth trying to wait an extra couple of weeks, if possible, to see if the other gland goes so your dog doesn’t have to go through two doses of anesthesia in a short period of time. Unfortunately, there is no way "preventive" surgery can be done, the gland actually has to come out before it can be repaired.

HYPOTHYROIDISM

The thyroid glands secrete a hormone which controls the basic metabolic rate of the entire body. Inadequate hormone levels reset the body to function at a lower metabolic level. In that case, dogs fatten easily on a normal diet, become sluggish, and are easily chilled. Hair changes are most noticeable and include loss of hair from the flanks and back, increased pigmentation of the skin, scaling and seborrhea (an abnormality in the production of skin cells.) secondary bacterial infection of the skin is common. The ears may also be affected, filling with thick, yellow greasy material which may predispose the dog to ear infections. Blood tests will determine the level of thyroid function and administration of thyroid hormone can treat the condition. Thyroid issues in Shar Pei can best be detected by having a 6 panel Thyroid test run…ideally the blood sample should be sent to Dr. Dodds at Hemopet (see links page) for the most accurate analysis and diagnosis.

FAMILIAL SHAR PEI FEVER (FSF)

*see also article above* Familial Shar-Pei fever also known as "Swollen Hock Syndrome" (SHS) typically may include the following symptoms: Swelling of the hock joint and sometimes other joints can be affected. Reluctance to move. Sometimes a swollen painful muzzle. Abdominal pain, vomiting, diarrhea, and shallow breathing. "Familial Shar-Pei Fever (FSF) is an episodic fever disorder. Shar-Pei with this disorder have one or more bouts of unexplained fever, usually 103-107 degrees but rare cases may go higher. Fevers usually start when they are less then 18 months old but sometimes the first attack is not until they are adults. Fever episodes usually become less frequent with age. Fevers last 24-36 hours in most cases without treatment". The disorder is "thought to result from an inability to regulate the auto-inflamatory system. Dogs suffering from this disorder are at risk of dying from a related disorder, amyloidosis. Dogs diagnosed with FSF/SHS should be maintained on a treatment protocol (either conventional or homeopathic) as early as possible to help prevent amyloidosis related organ failure. Affected Shar-Pei with amyloidosis have an inability to break down chemicals released in the bloodstream when inflammation results from abnormal deposition of amyloid protein throughout the body. While not all dogs with Shar-Pei fever die of amylodosis, when they do, death most commonly occurs between the ages of 3 and 5 years". While puppies can fever for a variety of reasons (infection, vaccine reaction insect bites/stings, reactions to toxins or certain meds) it is important when there is a fever to diagnose or rule out typical causes. FSF is an UNEXPLAINED series of fever episodes. If your puppy is given a "definitive" diagnosis of FSF thru appropriate diagnostic testing to rule out other causes and the history, clinical signs, it is essential to begin a treatment protocol ASAP to prevent potentialy deadly complications. For information on conventional protocols (Colchicine) see Dr. Vidt's & Dr. Tintle's website and for Homeopathic protocols see Pets 4 Homeopathy website (on our "links" page).

PATELLAR LUXATION

Is where the knee cap slips out of its socket. Any Shar-Pei with this condition should not be bred.

HIP DYSPLASIA

A dysplastic dog has an abnormal hip joint where the femur and acetabulum are misaligned. This can range in severity from mild (controllable) pain to dogs in such agony they must be put down. Make sure the parents of any puppy you consider has been cleared of Hip Dysplasia through the Orthopedic Foundation for Animals. (see links page for OFA website for further info)

REGURGITATION/VOMITING

REGURGITATION/VOMITING Megaesophagus and/or diaphramatic or hiatal hernias may or may not be detected until the dog is much older when they will appear underweight or emaciated with a history of vomiting. This is a developmental defect possibly a delayed maturation of the esophageal neuromuscular system. Primary symptoms to watch for is frequent regurgitation and a history of upper respiratory infections/pneumonia. Many Vets will not catch this initially as this is not a common condition, so if you note these symptoms ask your Vet to check for this specifically. Mild cases in young dogs can sometimes improve with careful feeding and management. Extreme cases may require intensive levels of care and feeding. There are also new techniques being used to treat this, including surgical repair that, while a relatively new procedure, is showing some very successful results. For more information on MegaEsophagus and related conditions and treatment/management options for these see info at the link below. Canine MegaEsophagus page MegaEsophagus is thought to be genetic in some cases. Afflicted dogs and close familial relatives of such should not be bred.

CUTANEOUS MUCINOSIS

Mucin is the substance in the Shar-Pei skin that causes all the wrinkling. It is clear and stringy and acts like glue in fight wounds." Some Shar-Pei have an excess of Mucin causing it to form clear bubbles on the skin that may rupture and ooze. May be associated with possible allergies and can be treated by a alternate day steriod therapy. Mucin is what makes Shar-Pei skin wrinkle and gives them padding on their muzzles and hocks. It is normal for Shar-Pei. Sometimes excessive mucin bubbles up in the skin, forming vesicles. This is called cutaneous mucinosis. These vesicles can be fragile and spontaneously break if the condition is severe or the bubbles of mucin may rupture during rough play, etc., causing the sticky substance to ooze out. It is normally not a problem for the dog. If it is excessive, e.g. causing much spontaneous rupture followed by healing scabby areas or if the skin is tearing frequently, the production of mucin can be shut down by low dosages of prednisone or other corticosteroids. Usually very low doses of alternate day prednisone result in dramatic improvement. If it is not bothering the dog, I would not treat it because corticosteroids are not without risk. Sometimes Shar-Pei will “lose” their muzzles because of steroids administered medically or because they are stressed by fever or illness and their own body’s production of cortisol by the adrenal glands will cause the mucin to “shrink”. Usually, they will return to normal with time but sometimes they never regain their old appearance. Many have used the supplement MSM to successfully manage mucinosis, this of course is preferable to steroids. Mucinosis frequently occurs on the neck, forelimbs, shoulder area, hocks and about the anus. Many individuals have had good success using MSM (supplement) for managing mucinosis outbreaks.

TORSION/BLOAT

Being one of many deep chested breeds, bloat can occur in Shar-Pei. Although similar to colic in horses, "bloat and torsion occur when the stomach swells with gas and then twists and cuts off its blood supply. Without timely surgical intervention the condition is fatal". The dog must see a veterinarian as soon as possible.

CHRONIC INFLAMATORY BOWEL DISEASE

Often complicated by food allergies and or Chronic stress diarrhea. Usually responds to a strict hypoallergenic diet.

CANCER

In regard to cancer, several forms have a high incidence in the breed. At present, the CSPCA is surveying club members to determine which are most prevalent. Once isolated, the organization's Charitable Trust plans to fund relevant cancer research.

ALLERGIES

Inhalant allergies are not uncommon in dogs. The symptoms generally express themselves in hair loss, intense itching and infected ears, watery/irritated eyes, clear nasal discharge, the skin between the toes of the feet might well be swollen and red. Allergies are caused by an overreaction of the immune system and again can be split into two groups, acquired and inherited. Acquired allergies show up in a mature dog which previously never had any problems. Trying to find the offending substance can be like searching for a needle in a haystack, various allergy tests are offered and can be either by the traditional "skin scrape" method or by blood tests. The blood test is mostly used in an attempt to track food allergies, it is not a terribly reliable test, but it is useful in indicating what direction to go in. The "skin scrape" is similar to the kind of testing done in people. Food allergies, whilst hard to track down are pretty rare also relatively easy to treat - the offending food substance is removed from the dog's diet. The best way to prevent food allergies is to feed your dog a high quality, PREMIUM dog food, (without soy, corn or wheat). Or feeding a natural diet (RAW or homecooked that is grain free). This is the same for a food intolerance. A food intolerance is common when we feed significant amounts of inappropriate foods for a specific species…like grain based foods to dogs. Inhalant allergies are, for the most part, impossible to eliminate but often can be treated/managed. Inhalant allergies are generally worse in the and fall when pollen, molds and seeds are abundant. Antihistamines may help control the symptoms. As with people, it is possible to get "allergy" shots for dogs which might help to alleviate some of the symptoms. Inherited allergies will generally show up in a much younger dog, sometimes as young as three months but nearly always by the time a dog has turned a year. Again dogs with inherited allergies should NEVER be bred. The treatment for dogs with inherited allergies is the same as for those with acquired.

FLEAS

Another very common cause of skin problems are fleas. Many dogs are very sensitive to the saliva of the flea and some are highly allergic. Symptoms are mild to intense itching and scratching; it can take only one bite to set a severely sensitive or allergic dog into ripping its skin apart. The best solution for fleabite sensitivities/allergies is PREVENTION. These days there are some excellent flea preventives available, both Frontline and Advantage are highly recommended, Program is another method, however this particular method does not actually kill the fleas that are biting your dog but sterilizes them so they can’t re-produce. If fleas are a problem you also have to treat the environment your dog lives in by removing fleas from your house and yard and treat the environment repeatedly as new eggs hatch. Diatoms are a natural solution that we advise to destroy flea eggs in the environment (home & yard).

SKIN ISSUES

  


SKIN ISSUES OVERVIEW
By JL Wortham-Morgan

Skin issues, though not life threatening, are often the most frustrating.
Since skin issues can be caused by a number of things and accurate diagnostic
testing for such can be challenging, invasive and expensive, often we look
first to the most probable causes and eliminate these as we go along. Even
more challenging is that many skin issues can easily become combo
issues.....multiple causes due to reactions, immunosuppression and chemical
imbalances. Once the body's natural defenses have been challenged by one
issue, other opportunistic organisms can gain a foothold. Also some treatment
protocols can complicate matters. It is essential to find and eliminate/manage
the root cause AND prevent or treat secondary issues at the same time.

It is VERY important to learn all you can....do not depend on your Vet to have
all the answers...some Vets are better with skin issues and Breed specific
issues than others. Empower yourself with knowledge, do some online research
and DO NOT allow yourself to be intimidated by your Vet. If you arm yourself
with knowledge you will know if your Vet's treatment protocol is logical and
appropriate....if it is not, challenge it or seek another Vet.

Most common causes of skin issues are generally as follows:

1)Fleas.....fleas can cause a number of issues and lead to secondary issues.
Flea sensitivity which is normal inflammation/reaction to flea bite. Itching
leads to chewing which can lead to bacterial infections, etc. Actual flea
allergies which are similar in symptom type though much more intense reactions.

2)Pyoderma (bacterial infection, usually staph). (symptoms: Hair loss,
redness/inflammation, pustuals/pimples, lesions, skin, odor, itching) This can
be either a primary cause (due to immature or suppressed immune system) or a
secondary issue. Bacterial infections of the skin need to be treated with an
appropriate antibiotic protocol of sufficient doses, for extended periods of
at least 2-3 weeks following cessation of all symptoms. This is because Staph
bacteria is extremely tenacious and is often resistant to antibiotics. It
usually takes at least 2-3 weeks to even begin to see clear improvement with
antibiotics. Often antibiotic protocols for Pyoderma are ineffective for the
following reasons: The antibiotic was not the appropriate antibiotic for the
specific bacterial strain, the dosage was insufficient, the course of
treatment was not long enough to wipe out the bacterial population OR there is
an underlying or secondary issue that hasn't been dealt with.

Appropriate antibiotic will vary due to resistant strains. Generally the drug
of choice for treating this is Cephalosporins (broad spectrum antibiotic).

In cases of resistant bacterial strains (evident by either lack of improvement
on the Cephalosporins after several weeks or relapse following FULL course of
treatment)....the next step is often to have a culture and sensitivity test
run to see which antibiotic is most effective. Often a more narrow spectrum
antibiotic that is specifically targeting a bacterial strain that is sensitive
to it will be prescribed with resistant Pyoderma.

While on any antibiotics it is especially important to manage diet to
prevent/counter yeast overgrowth. See below #3

3)Yeast overgrowth. (symptoms: Hair loss, redness/inflammation (especially 
in armpits, groin, neck and chin, between toes), weeping lesions/skin, odor,
itching, chronic ear infections) This can be a primary issue or secondary to
other issues. To eliminate this is a 4 pronged approach: 1/ Eliminate sugars
and excess refined carbohydrates from the diet. Feed low grain or no grain
diets with "cool carbs" instead of grains....and no sugar of any kind. 2/Add
probiotics to the diet: plain yogurt, acidophilus, enzymes or such
supplements. 3/ Adjust body PH....1-2 teaspoons plain vinegar to drink water
daily. 4/ Topical preparations like colodial silver spray, Monistat cream or
SharpSue's Pei Powder (recipe below) may help.

SharpSue's Pei Powder recipe: 1 part boric acid to 6 parts cornstach. Place
the powder in a terry washcloth( this sifts the powder really fine, and is why
it works so well) And tie or rubberband the cloth shut. (a powder puff) Dust
the effected areas with the puff. Do this two to three times a day.

4)Demodectic Mange mite overpopulation. Note: Demodex is NOT contagious.
(Symptoms: hairloss either in patches or thinning "moth eaten" patterns).
With straight up demodex you don't usually see itching or redness. This may,
(and often is), however accompanied by other issues....usually bacterial
and/or yeast, so all symptoms may manifest for these issues. Localized demodex
is usually confined to an area or is just a limited number of effected
areas....if the immune system is not compromised, this may clear up on it's
own or be "spot treated" topically. Generalized demodex can occur for a number
of reasons, some genetic others not. In immature immune system may not yet be
sufficiently developed to counter a demodex overgrowth. Use of steroids can
cause a demodex infection to go generalized. An illness or a genetic issue can
cause the immune system to be compromised and thus be followed by generalized
demodex.

IMPORTANT NOTE: Often skin scrappings are inadequate as a diagnostic tool for
demodex in this breed due to the unique nature of their skin, (probably due to
the high mucicin....that's my guess on it anyway). Most skin scrappings will
return negative results even when there is a demodex issue present. The only
adequate way to test a Pei accurately for this is a skin biopsy....since this
is expensive and invasive, many Pei experienced Vets will forgo this and
simply treat if mange is suspected. Other vets will run scrapping after
scrapping (at your expense) while the mange goes unchecked.

Demodex is generally treated with either a serious of special dips or
injections that your Vet may prescribe. Any underlying causes should be tested
for and any secondary issues need to be treated/managed simultaneously.

5)Environmental agents can cause irritations, sensitivities or even true
allergic responses. One must determine what in the immediate environment may
be the cause. Household chemicals/cleaners/deoderizers etc., pesticides,
herbicides, lawn products. Seasonal issues with inhalent allergies, etc. One
must meticulously inventory and monitor any potential environmental cause and
eliminate or limit exposure.

6)Food allergies. Food allergies rarely manifest as skin issues. It CAN
happen....just isn't the most likely culprit. Elimination diets, diets that
limit ingredients and additives can help to determine the presence of food
allergies. There is also allergy sensitivity testing available. Although food
allergies are uncommon, many dogs do not tolerate Grains well….many are also
sensitive specifically to wheat, corn or soy. Try a low grain or no-grain food.

7)Thyroid issues. (Symptoms: Unexplained weight gain, Thin or "coarse" coat,
Greasy skin/coat (even right after a bath), Regurgitates his/her food
(different than vomiting -- time factor)(other megaesophagus symptoms),
Aggressiveness,  Slow heart beat, Possible seizures, Stiffness, cold
intolerance, Lethargy, Hyperexcitability, Chronic offensive skin odor).
Thyroid issues are considered genetic and as with any suspected genetic issue
the animal should not be bred. Thyroid testing (full 6 panel test). Thyroid
issues can be treated. Ideally the test should be done by sending the blood
sample (drawn by your Vet) to Dr. Dodds at Hemopet (link below) for testing
and evaluation.

http://www.itsfortheanimals.com/HEMOPET.HTM

8)Other underlying causes of skin issues may include Cushings disease and
other possible factors including auto immune disorders and immune deficient
disorders. 
Some theories say vaccines(over vaccination and vaccine reactions) may
contribute to some of these issues.

Most skin issues I have seen or heard of occur around "adolesence" as the
immune system is maturing. Especially around the ages of 4-8 months. This is
the time when Mother's immunity is wearing off and the developing immune
system is struggling to take over the job. This is ALSO the time when we are
challenging the young immune system with a barage of vaccines. I feel that
during this age of susceptibility we need to be extra careful both to minimize
insult to the immune system AND offer additional immune support as it is
developing.

To minimize overloading the maturing immune system we adjust vaccine protocols
during this time especially. I avoid "comb vaccines" and alternate “Core”
vaccines (of the major threats Parvo, Distemper, Corona, Rabies). I avoid
Lepto vaccines prior to 6 months and I avoid Bordtadella vaccines altogether.
I also give supplements for immune support during this time. I give 500mg
Ester C, 200-400 IU Vitamine E and 500-1000 mg MSM daily.

AND.....do NOT allow treatment with systemic Steroids to control inflammation,
itching, etc. The only time steroids should be used to treat skin issues is
when you have a confirmed diagnosis (thru allergy sensitivity testing) of
chronic allergies that cannot be managed any other way....AND any possibility
of infection has been definitively ruled out.

Steroids used systemically suppress the immune system and will not only
complicate or even create a skin issue due to infection, they can invite
numerous other issues as they compromise immune system function.

Topical Steroids can be used in cases of extreme itching/inflamation but are
not generally recommended in cases of infection.